The use of chimeric antigen receptor (CAR) in natural killer (NK) cells for cancer therapy is gaining momentum, marking a significant shift in cancer treatment.This review aims to explore the potential of Bottle Pourer CAR-NK cell therapy in cancer immunotherapy, providing a fresh perspective.It discusses the innovative approaches in CAR-NK cell design and engineering, particularly targeting refractory or recurrent cancers.By comparing CAR-NK cells with traditional breastcollar#Breastplate therapies, the review highlights their unique ability to tackle tumor heterogeneity and immune system suppression.
Additionally, it explains how novel cytokines and receptors can enhance CAR-NK cell efficacy, specificity, and functionality.This review underscores the advantages of CAR-NK cells, including reduced toxicity, lower cost, and broader accessibility compared to CAR-T cells, along with their potential in treating both blood cancers and solid tumors.